Genetics of Male Infertility: A Case-Based Guide for Clinicians (Hardcover)

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Genetics of Male Infertility: A Case-Based Guide for Clinicians By Mohamed Arafa (Editor), Haitham Elbardisi (Editor), Ahmad Majzoub (Editor) Cover Image
By Mohamed Arafa (Editor), Haitham Elbardisi (Editor), Ahmad Majzoub (Editor)
$179.99
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Description


This unique, case-based guide provides a thoughtful and comprehensive overview of the genetic basis of male infertility for the practicing clinician. In addition to discussing the molecular foundations of sperm production and the consequences of genetic abnormalities on various stages of sperm development, it examines the clinical aspects of acknowledged genetic disorders and their implications on male fertility. In so doing, it offers the necessary tools required by the clinician for the diagnosis and treatment of infertile men with genetic abnormalities. Moreover, it provides essential algorithms that may aid in counseling patients in the clinic.
The text is arranged in four thematic sections for easy reference. The genetic foundation of male reproduction is presented in part 1, including regulation of sperm production, the structure of sperm chromatin, and spermatogenesis. The impact of genetic abnormalities on male infertility is the subject of part 2, covering sperm defects, mitochondrial function and DNA fragmentation. The clinical case material in part 3 illustrates real-world examples of genetic etiologies and the current diagnostic and therapeutic strategies for conditions such as vas asplasia, cryptorchidism, immotile cilia syndrome, sperm aneuploidy and other challenging scenarios. Casting forward, the fourth and final section presents an overview of future possibilities for management of genetic causes of male infertility, including gene editing.
Fully exploring the clinical context of these genetic conditions in a practical manner that appeals to the practicing clinician, Genetics of Male Infertility is an exciting and essential text for reproductive medicine specialists, andrologists, urologists, researchers and all other clinicians treating infertile patients.

About the Author


Mohamed Arafa, MD, Department of Andrology, Cairo University, Cairo, Egypt; Department of Urology, Hamad Medical Corporation, Doha, Qatar; Department of Urology, Weill Cornell Medicine - Qatar, Doha, Qatar Haitham Elbardisi, MD, Department of Urology, Hamad Medical Corporation, Doha, Qatar; Department of Urology, Weill Cornell Medicine - Qatar, Doha, Qatar Ahmad Majzoub, MD, Department of Urology, Hamad Medical Corporation, Doha, Qatar; Department of Urology, Weill Cornell Medicine - Qatar, Doha, QatarAshok Agarwal, PhD, HCLD, American Center for Reproductive Medicine, Department of Urology, Cleveland Clinic, Cleveland, OH, USA
Product Details
ISBN: 9783030379711
ISBN-10: 303037971X
Publisher: Springer
Publication Date: March 15th, 2020
Pages: 375
Language: English